Comparative Study of the Synthesis of 7 Hydroxy-4-Methyl Coumarin Mannich Bases by Conventional and Microwave Method
نویسندگان
چکیده
Present work describes the synthesis of coumarin Mannich bases 4-7 by the application of Mannich reaction on 7-hydroxy-4-methyl coumarin 3 using conventional as well as microwave technology to compare the feasibility, reaction time and yield of the product. For this, 7-hydroxy-4-methyl coumarin 3 was prepared using Pechmann condensation reaction and Mannich bases (4-7) were synthesized by the reaction of 3 with various secondary amines. A comparison between the conventional and microwave methods demonstrated that the microwave assisted synthesis was more convenient and simpler method with better yield and lesser formation of by-products of compounds 4-7 as compared to conventional method of synthesis.
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